Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

Cellular senescence suppresses cancer by arresting cell proliferation, essentially permanently, in response to oncogenic stimuli, including genotoxic stress. We modified the use of antibody arrays to provide a quantitative assessment of factors secreted by senescent cells. We show that human cells i...

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Detalles Bibliográficos
Autores principales: Coppé, Jean-Philippe, Patil, Christopher K, Rodier, Francis, Sun, Yu, Muñoz, Denise P, Goldstein, Joshua, Nelson, Peter S, Desprez, Pierre-Yves, Campisi, Judith
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2592359/
https://www.ncbi.nlm.nih.gov/pubmed/19053174
http://dx.doi.org/10.1371/journal.pbio.0060301

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2592359/
https://www.ncbi.nlm.nih.gov/pubmed/19053174
http://dx.doi.org/10.1371/journal.pbio.0060301

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