Haploinsufficiency of Activation-Induced Deaminase for Antibody Diversification and Chromosome Translocations both In Vitro and In Vivo

The humoral immune response critically relies on the secondary diversification of antibodies. This diversification takes places through somatic remodelling of the antibody genes by two molecular mechanisms, Class Switch Recombination (CSR) and Somatic Hypermutation (SHM). The enzyme Activation Induc...

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Detalles Bibliográficos
Autores principales: Sernández, Isora V., de Yébenes, Virginia G., Dorsett, Yair, Ramiro, Almudena R.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2592691/
https://www.ncbi.nlm.nih.gov/pubmed/19079594
http://dx.doi.org/10.1371/journal.pone.0003927

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2592691/
https://www.ncbi.nlm.nih.gov/pubmed/19079594
http://dx.doi.org/10.1371/journal.pone.0003927

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