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Focal distortion of the nuclear envelope by huntingtin aggregates revealed by lamin immunostaining
Huntington’s disease is an autosomal dominant neurodegenerative disorder caused by the expansion of a polyglutamine repeat tract in the huntingtin protein. Polyglutamine-expanded huntingtin forms intranuclear as well as perinuclear inclusion bodies. Perinuclear aggregates formed by polyglutamine-exp...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Scientific Publishers Ireland
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2593798/ https://www.ncbi.nlm.nih.gov/pubmed/18840504 http://dx.doi.org/10.1016/j.neulet.2008.09.075 |