SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth

Cell growth (accumulation of mass) needs to be coordinated with metabolic processes that are required for the synthesis of macromolecules. The PI3-kinase/Akt signaling pathway induces cell growth via activation of complex 1 of the target of rapamycin (TORC1). Here we show that Akt-dependent lipogene...

Descripción completa

Detalles Bibliográficos
Autores principales: Porstmann, Thomas, Santos, Claudio R., Griffiths, Beatrice, Cully, Megan, Wu, Mary, Leevers, Sally, Griffiths, John R., Chung, Yuen-Li, Schulze, Almut
Formato: Texto
Lenguaje:English
Publicado: Cell Press 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2593919/
https://www.ncbi.nlm.nih.gov/pubmed/18762023
http://dx.doi.org/10.1016/j.cmet.2008.07.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2593919/
https://www.ncbi.nlm.nih.gov/pubmed/18762023
http://dx.doi.org/10.1016/j.cmet.2008.07.007

Ejemplares similares