Heterosubtypic Neutralizing Monoclonal Antibodies Cross-Protective against H5N1 and H1N1 Recovered from Human IgM(+) Memory B Cells

BACKGROUND: The hemagglutinin (HA) glycoprotein is the principal target of protective humoral immune responses to influenza virus infections but such antibody responses only provide efficient protection against a narrow spectrum of HA antigenic variants within a given virus subtype. Avian influenza...

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Detalles Bibliográficos
Autores principales: Throsby, Mark, van den Brink, Edward, Jongeneelen, Mandy, Poon, Leo L. M., Alard, Philippe, Cornelissen, Lisette, Bakker, Arjen, Cox, Freek, van Deventer, Els, Guan, Yi, Cinatl, Jindrich, ter Meulen, Jan, Lasters, Ignace, Carsetti, Rita, Peiris, Malik, de Kruif, John, Goudsmit, Jaap
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2596486/
https://www.ncbi.nlm.nih.gov/pubmed/19079604
http://dx.doi.org/10.1371/journal.pone.0003942

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2596486/
https://www.ncbi.nlm.nih.gov/pubmed/19079604
http://dx.doi.org/10.1371/journal.pone.0003942

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