Phospholipase A(2) reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease

Neuronal expression of familial Alzheimer's disease (AD)-mutant human amyloid precursor protein (hAPP) and hAPP-derived amyloid-β (Aβ) peptides causes synaptic dysfunction, inflammation, and abnormal cerebrovascular tone in transgenic mice. Fatty acids may be involved in these processes, but th...

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Detalles Bibliográficos
Autores principales: Sanchez-Mejia, Rene O., Newman, John W., Toh, Sandy, Yu, Gui-Qiu, Zhou, Yungui, Halabisky, Brian, Cissé, Moustapha, Scearce-Levie, Kimberly, Cheng, Irene H., Gan, Li, Palop, Jorge J., Bonventre, Joseph V., Mucke, Lennart
Formato: Texto
Lenguaje:English
Publicado: 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2597064/
https://www.ncbi.nlm.nih.gov/pubmed/18931664
http://dx.doi.org/10.1038/nn.2213

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2597064/
https://www.ncbi.nlm.nih.gov/pubmed/18931664
http://dx.doi.org/10.1038/nn.2213

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