Cargando…

Essential Role of TGF-β/Smad Pathway on Statin Dependent Vascular Smooth Muscle Cell Regulation

BACKGROUND: The 3-hydroxy-3-methylglutaryl CoA reductase inhibitors (also called statins) exert proven beneficial effects on cardiovascular diseases. Recent data suggest a protective role for Transforming Growth Factor-β (TGF-β) in atherosclerosis by regulating the balance between inflammation and e...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rodríguez-Vita, Juan, Sánchez-Galán, Eva, Santamaría, Beatriz, Sánchez-López, Elsa, Rodrigues-Díez, Raquel, Blanco-Colio, Luís Miguel, Egido, Jesús, Ortiz, Alberto, Ruiz-Ortega, Marta
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2597201/ https://www.ncbi.nlm.nih.gov/pubmed/19088845 http://dx.doi.org/10.1371/journal.pone.0003959

Ejemplares similares

Statins Inhibit Angiotensin II/Smad Pathway and Related Vascular Fibrosis, by a TGF-β-Independent Process
por: Rodrigues Díez, Raúl, et al.
Publicado: (2010)

CCN2 Increases TGF-β Receptor Type II Expression in Vascular Smooth Muscle Cells: Essential Role of CCN2 in the TGF-β Pathway Regulation
por: Tejera-Muñoz, Antonio, et al.
Publicado: (2021)

Statins: Could an old friend help in the fight against COVID‐19?
por: Rodrigues‐Diez, Raul R., et al.
Publicado: (2020)

Gremlin Activates the Smad Pathway Linked to Epithelial Mesenchymal Transdifferentiation in Cultured Tubular Epithelial Cells
por: Rodrigues-Diez, Raquel, et al.
Publicado: (2014)

TGF-Beta Blockade Increases Renal Inflammation Caused by the C-Terminal Module of the CCN2
por: Rodrigues-Díez, Raquel, et al.
Publicado: (2015)

Cellular Crosstalk between Endothelial and Smooth Muscle Cells in Vascular Wall Remodeling
por: Méndez-Barbero, Nerea, et al.
Publicado: (2021)

TWEAK Promotes Peritoneal Inflammation
por: Sanz, Ana Belen, et al.
Publicado: (2014)

Tweak induces proliferation in renal tubular epithelium: a role in uninephrectomy induced renal hyperplasia
por: Sanz, Ana B, et al.
Publicado: (2009)

TGF-β/Smad3 Stimulates Stem Cell/Developmental Gene Expression and Vascular Smooth Muscle Cell De-Differentiation
por: Shi, Xudong, et al.
Publicado: (2014)

Endogenous sulfur dioxide alleviates collagen remodeling via inhibiting TGF-β/Smad pathway in vascular smooth muscle cells
por: Huang, Yaqian, et al.
Publicado: (2016)

Restenosis Inhibition and Re-differentiation of TGFβ/Smad3-activated Smooth Muscle Cells by Resveratrol
por: Zhu, Yichen, et al.
Publicado: (2017)

Calcineurin inhibitors cyclosporine A and tacrolimus induce vascular inflammation and endothelial activation through TLR4 signaling
por: Rodrigues-Diez, Raquel, et al.
Publicado: (2016)

TWEAK Activates the Non-Canonical NFκB Pathway in Murine Renal Tubular Cells: Modulation of CCL21
por: Sanz, Ana B., et al.
Publicado: (2010)

Correction: TGF-β/Smad3 Stimulates Stem Cell/Developmental Gene Expression and Vascular Smooth Muscle Cell De-Differentiation
Publicado: (2014)

TGF-β/Smad3 inhibit vascular smooth muscle cell apoptosis through an autocrine signaling mechanism involving VEGF-A
por: Shi, X, et al.
Publicado: (2014)

TrkB-Induced Inhibition of R-SMAD/SMAD4 Activation is Essential for TGF-β-Mediated Tumor Suppressor Activity
por: Kim, Min Soo, et al.
Publicado: (2020)

Phosphoinositide-binding activity of Smad2 is essential for its function in TGF-β signaling
por: Buwaneka, Pawanthi, et al.
Publicado: (2021)

Cardiomyocyte SMAD4-Dependent TGF-β Signaling is Essential to Maintain Adult Heart Homeostasis
por: Umbarkar, Prachi, et al.
Publicado: (2019)

MicroRNA-29b inhibits human vascular smooth muscle cell proliferation via targeting the TGF-β/Smad3 signaling pathway
por: Li, Lirong, et al.
Publicado: (2021)

TGF-β/Smad3 Signalling Modulates GABA Neurotransmission: Implications in Parkinson’s Disease
por: Muñoz, Mª Dolores, et al.
Publicado: (2020)

TGF-β/Smad signaling in renal fibrosis
por: Meng, Xiao-Ming, et al.
Publicado: (2015)

Common pathways of hypercholesterolemia and hypertension leading to atherothrombosis: the need for a global approach in the management of cardiovascular risk factors
por: Tuñón, José, et al.
Publicado: (2007)

Role of TGF-β1/Smad3 Signaling Pathway in Secretion of Type I and III Collagen by Vascular Smooth Muscle Cells of Rats Undergoing Balloon Injury
por: Lu, Ping, et al.
Publicado: (2012)

TGF-Beta Induced Erk Phosphorylation of Smad Linker Region Regulates Smad Signaling
por: Hough, Chris, et al.
Publicado: (2012)

SMAD2/3 mediate oncogenic effects of TGF-β in the absence of SMAD4
por: Bertrand-Chapel, Adrien, et al.
Publicado: (2022)

Modulation of calcification of vascular smooth muscle cells in culture by calcium antagonists, statins, and their combination
por: Trion, Astrid, et al.
Publicado: (2007)

Smad4-mediated TGF-β signaling in tumorigenesis
por: Yang, Guan, et al.
Publicado: (2010)

The regulation of TGF-β/SMAD signaling by protein deubiquitination
por: Zhang, Juan, et al.
Publicado: (2014)

The role of TGF-β/SMAD4 signaling in cancer
por: Zhao, Ming, et al.
Publicado: (2018)

TGF-β/Smad Signaling Pathway in Tubulointerstitial Fibrosis
por: Yu, Xiao-Yong, et al.
Publicado: (2022)

Effect of progesterone on Smad signaling and TGF-β/Smad-regulated genes in lung epithelial cells
por: Kunzmann, Steffen, et al.
Publicado: (2018)

Liver fibrosis secondary to bile duct injury: correlation of Smad7 with TGF-β and extracellular matrix proteins
por: del Pilar Alatorre-Carranza, María, et al.
Publicado: (2009)

Smad2 inhibition of MET transcription potentiates human vascular smooth muscle cell apoptosis
por: Xie, Xiujie, et al.
Publicado: (2021)

Oxidative Stress in Human Atherothrombosis: Sources, Markers and Therapeutic Targets
por: Martin-Ventura, Jose Luis, et al.
Publicado: (2017)

Hyperlipidemia-Associated Renal Damage Decreases Klotho Expression in Kidneys from ApoE Knockout Mice
por: Sastre, Cristina, et al.
Publicado: (2013)

Angiotensin II Contributes to Renal Fibrosis Independently of Notch Pathway Activation
por: Lavoz, Carolina, et al.
Publicado: (2012)

Vascular smooth muscle ion channels in essential hypertension
por: Daghbouche-Rubio, Nuria, et al.
Publicado: (2022)

The expression of TGF-β1, Smad3, phospho-Smad3 and Smad7 is correlated with the development and invasion of nonfunctioning pituitary adenomas
por: Zhenye, Li, et al.
Publicado: (2014)

Glycoprotein M6B Interacts with TβRI to Activate TGF‐β‐Smad2/3 Signaling and Promote Smooth Muscle Cell Differentiation
por: Zhang, Xiaomeng, et al.
Publicado: (2018)

Somatic SMAD3-activating mutations cause melorheostosis by up-regulating the TGF-β/SMAD pathway
por: Kang, Heeseog, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_d6udq199gqiism71aiiuq5bd8c