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Ion Channel Clustering at the Axon Initial Segment and Node of Ranvier Evolved Sequentially in Early Chordates
In many mammalian neurons, dense clusters of ion channels at the axonal initial segment and nodes of Ranvier underlie action potential generation and rapid conduction. Axonal clustering of mammalian voltage-gated sodium and KCNQ (Kv7) potassium channels is based on linkage to the actin–spectrin cyto...
Autores principales: | Hill, Alexis S., Nishino, Atsuo, Nakajo, Koichi, Zhang, Giuxin, Fineman, Jaime R., Selzer, Michael E., Okamura, Yasushi, Cooper, Edward C. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2597720/ https://www.ncbi.nlm.nih.gov/pubmed/19112491 http://dx.doi.org/10.1371/journal.pgen.1000317 |
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