The Pace of Prostatic Intraepithelial Neoplasia Development Is Determined by the Timing of Pten Tumor Suppressor Gene Excision

Loss of the PTEN tumor suppressor is a common occurrence in human prostate cancer, particularly in advanced disease. In keeping with its role as a pivotal upstream regulator of the phosphatidylinositol 3-kinase signaling pathway, experimentally-induced deletion of Pten in the murine prostate invaria...

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Detalles Bibliográficos
Autores principales: Luchman, H. Artee, Benediktsson, Hallgrimur, Villemaire, Michelle L., Peterson, Alan C., Jirik, Frank R.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2597775/
https://www.ncbi.nlm.nih.gov/pubmed/19081794
http://dx.doi.org/10.1371/journal.pone.0003940

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2597775/
https://www.ncbi.nlm.nih.gov/pubmed/19081794
http://dx.doi.org/10.1371/journal.pone.0003940

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