Antiproliferative activity of PEP005, a novel ingenol angelate that modulates PKC functions, alone and in combination with cytotoxic agents in human colon cancer cells

PEP005 is a novel ingenol angelate that modulates protein kinases C (PKC) functions by activating PKCδ and inhibiting PKCα. This study assessed the antiproliferative effects of PEP005 alone and in combination with several other anticancer agents in a panel of 10 human cancer cell lines characterised...

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Detalles Bibliográficos
Autores principales: Benhadji, K A, Serova, M, Ghoul, A, Cvitkovic, E, Le Tourneau, C, Ogbourne, S M, Lokiec, F, Calvo, F, Hammel, P, Faivre, S, Raymond, E
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2008
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2600681/
https://www.ncbi.nlm.nih.gov/pubmed/19034280
http://dx.doi.org/10.1038/sj.bjc.6604642

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2600681/
https://www.ncbi.nlm.nih.gov/pubmed/19034280
http://dx.doi.org/10.1038/sj.bjc.6604642

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