Isothiocyanate NB7M causes selective cytotoxicity, pro-apoptotic signalling and cell-cycle regression in ovarian cancer cells

The present report identifies indole-3-ethyl isothiocyanate NB7M as a potent cytotoxic agent with selective activity against cell lines derived from various tumour types. Ovarian cancer cell lines showed sensitivity to NB7M (60–70% cytotoxicity at 2.5 μM), in contrast to control cells (TCL-1 and HTR...

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Detalles Bibliográficos
Autores principales: Singh, R K, Lange, T S, Kim, K K, Singh, A P, Vorsa, N, Brard, L
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2008
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2600706/
https://www.ncbi.nlm.nih.gov/pubmed/19002174
http://dx.doi.org/10.1038/sj.bjc.6604778

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2600706/
https://www.ncbi.nlm.nih.gov/pubmed/19002174
http://dx.doi.org/10.1038/sj.bjc.6604778

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