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Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity
α-synuclein (α-syn) is a main component of Lewy bodies (LB) that occur in many neurodegenerative diseases, including Parkinson's disease (PD), dementia with LB (DLB) and multi-system atrophy. α-syn mutations or amplifications are responsible for a subset of autosomal dominant familial PD cases,...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2600785/ https://www.ncbi.nlm.nih.gov/pubmed/19021916 http://dx.doi.org/10.1186/1756-6606-1-17 |