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A NMR strategy to unambiguously distinguish nucleic acid hairpin and duplex conformations applied to a Xist RNA A-repeat

All RNA sequences that fold into hairpins possess the intrinsic potential to form intermolecular duplexes because of their high self-complementarity. The thermodynamically more stable duplex conformation is favored under high salt conditions and at high RNA concentrations, posing a challenging probl...

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Detalles Bibliográficos
Autores principales: Duszczyk, Malgorzata M., Zanier, Katia, Sattler, Michael
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2602763/
https://www.ncbi.nlm.nih.gov/pubmed/18987004
http://dx.doi.org/10.1093/nar/gkn776