The Polybasic Region of Rac1 Modulates Bacterial Uptake Independently of Self-association and Membrane Targeting

The COOH-terminal polybasic region (PBR) of Rac1, a Rho family GTPase member, is required for Rac1 self-association, membrane localization, nuclear translocation, and interaction with downstream effectors. We previously demonstrated that phosphatidylinositol-4-phosphate 5-kinase, one of the effector...

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Detalles Bibliográficos
Autores principales: Wong, Ka-Wing, Mohammadi, Sina, Isberg, Ralph R.
Formato: Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2008
Materias:
Mechanisms of Signal Transduction
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2602895/
https://www.ncbi.nlm.nih.gov/pubmed/18940795
http://dx.doi.org/10.1074/jbc.M804717200

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2602895/
https://www.ncbi.nlm.nih.gov/pubmed/18940795
http://dx.doi.org/10.1074/jbc.M804717200

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