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The Polybasic Region of Rac1 Modulates Bacterial Uptake Independently of Self-association and Membrane Targeting

The COOH-terminal polybasic region (PBR) of Rac1, a Rho family GTPase member, is required for Rac1 self-association, membrane localization, nuclear translocation, and interaction with downstream effectors. We previously demonstrated that phosphatidylinositol-4-phosphate 5-kinase, one of the effector...

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Detalles Bibliográficos
Autores principales:	Wong, Ka-Wing, Mohammadi, Sina, Isberg, Ralph R.
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2008
Materias:	Mechanisms of Signal Transduction
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2602895/ https://www.ncbi.nlm.nih.gov/pubmed/18940795 http://dx.doi.org/10.1074/jbc.M804717200

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