Clofazimine Inhibits Human Kv1.3 Potassium Channel by Perturbing Calcium Oscillation in T Lymphocytes

The Kv1.3 potassium channel plays an essential role in effector memory T cells and has been implicated in several important autoimmune diseases including multiple sclerosis, psoriasis and type 1 diabetes. A number of potent small molecule inhibitors of Kv1.3 channel have been reported, some of which...

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Bibliographic Details
Main Authors: Ren, Yunzhao R., Pan, Fan, Parvez, Suhel, Fleig, Andrea, Chong, Curtis R., Xu, Jing, Dang, Yongjun, Zhang, Jin, Jiang, Hongsi, Penner, Reinhold, Liu, Jun O.
Format: Text
Language:English
Published: Public Library of Science 2008
Subjects:
Research Article
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2602975/
https://www.ncbi.nlm.nih.gov/pubmed/19104661
http://dx.doi.org/10.1371/journal.pone.0004009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2602975/
https://www.ncbi.nlm.nih.gov/pubmed/19104661
http://dx.doi.org/10.1371/journal.pone.0004009

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