Structural insights into phenylethanolamines high-affinity binding site in NR2B from binding and molecular modeling studies

BACKGROUND: Phenylethanolamines selectively bind to NR2B subunit-containing N-methyl-D-aspartate-subtype of ionotropic glutamate receptors and negatively modulate receptor activity. To investigate the structural and functional properties of the ifenprodil binding domain on the NR2B protein, we have...

Descripción completa

Detalles Bibliográficos
Autores principales: Ng, Fui-Mee, Geballe, Matthew T, Snyder, James P, Traynelis, Stephen F, Low, Chian-Ming
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2603005/
https://www.ncbi.nlm.nih.gov/pubmed/19017396
http://dx.doi.org/10.1186/1756-6606-1-16

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2603005/
https://www.ncbi.nlm.nih.gov/pubmed/19017396
http://dx.doi.org/10.1186/1756-6606-1-16

Ejemplares similares