An Analysis of Enzyme Kinetics Data for Mitochondrial DNA Strand Termination by Nucleoside Reverse Transcription Inhibitors

Nucleoside analogs used in antiretroviral treatment have been associated with mitochondrial toxicity. The polymerase-γ hypothesis states that this toxicity stems from the analogs' inhibition of the mitochondrial DNA polymerase (polymerase-γ) leading to mitochondrial DNA (mtDNA) depletion. We ha...

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Detalles Bibliográficos
Autores principales: Wendelsdorf, Katherine V., Song, Zhuo, Cao, Yang, Samuels, David C.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2603287/
https://www.ncbi.nlm.nih.gov/pubmed/19132079
http://dx.doi.org/10.1371/journal.pcbi.1000261

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2603287/
https://www.ncbi.nlm.nih.gov/pubmed/19132079
http://dx.doi.org/10.1371/journal.pcbi.1000261

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