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An Analysis of Enzyme Kinetics Data for Mitochondrial DNA Strand Termination by Nucleoside Reverse Transcription Inhibitors

Nucleoside analogs used in antiretroviral treatment have been associated with mitochondrial toxicity. The polymerase-γ hypothesis states that this toxicity stems from the analogs' inhibition of the mitochondrial DNA polymerase (polymerase-γ) leading to mitochondrial DNA (mtDNA) depletion. We ha...

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Detalles Bibliográficos
Autores principales:	Wendelsdorf, Katherine V., Song, Zhuo, Cao, Yang, Samuels, David C.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2603287/ https://www.ncbi.nlm.nih.gov/pubmed/19132079 http://dx.doi.org/10.1371/journal.pcbi.1000261

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