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Preventing β-amyloid fibrillization and deposition: β-sheet breakers and pathological chaperone inhibitors
Central to the pathogenesis of Alzheimer's disease (AD) is the conversion of normal, soluble β-amyloid (sAβ) to oligomeric, fibrillar Aβ. This process of conformational conversion can be influenced by interactions with other proteins that can stabilize the disease-associated state; these protei...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2604889/ https://www.ncbi.nlm.nih.gov/pubmed/19090993 http://dx.doi.org/10.1186/1471-2202-9-S2-S5 |