Structure and regulation of MARK, a kinase involved in abnormal phosphorylation of Tau protein

Protein kinases of the MARK family phosphorylate tau protein in its repeat domain and thereby regulate its affinity for microtubules and affect the aggregation of tau into Alzheimer paired helical filaments. We are searching for low molecular weight compounds to interfere with the activity of MARK a...

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Detalles Bibliográficos
Autores principales: Timm, Thomas, Marx, Alexander, Panneerselvam, Saravanan, Mandelkow, Eckhard, Mandelkow, Eva-Maria
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2604893/
https://www.ncbi.nlm.nih.gov/pubmed/19090997
http://dx.doi.org/10.1186/1471-2202-9-S2-S9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2604893/
https://www.ncbi.nlm.nih.gov/pubmed/19090997
http://dx.doi.org/10.1186/1471-2202-9-S2-S9

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