Structure and regulation of MARK, a kinase involved in abnormal phosphorylation of Tau protein

Protein kinases of the MARK family phosphorylate tau protein in its repeat domain and thereby regulate its affinity for microtubules and affect the aggregation of tau into Alzheimer paired helical filaments. We are searching for low molecular weight compounds to interfere with the activity of MARK a...

Descripción completa

Detalles Bibliográficos
Autores principales: Timm, Thomas, Marx, Alexander, Panneerselvam, Saravanan, Mandelkow, Eckhard, Mandelkow, Eva-Maria
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2604893/
https://www.ncbi.nlm.nih.gov/pubmed/19090997
http://dx.doi.org/10.1186/1471-2202-9-S2-S9
Descripción
Sumario:Protein kinases of the MARK family phosphorylate tau protein in its repeat domain and thereby regulate its affinity for microtubules and affect the aggregation of tau into Alzheimer paired helical filaments. We are searching for low molecular weight compounds to interfere with the activity of MARK and its pathways. Here we summarize structural features of MARK and cellular pathways of regulation.

Ejemplares similares