Cargando…

Induction of inflammatory and immune responses by HMGB1–nucleosome complexes: implications for the pathogenesis of SLE

Autoantibodies against double-stranded DNA (dsDNA) and nucleosomes represent a hallmark of systemic lupus erythematosus (SLE). However, the mechanisms involved in breaking the immunological tolerance against these poorly immunogenic nuclear components are not fully understood. Impaired phagocytosis...

Descripción completa

Detalles Bibliográficos
Autores principales: Urbonaviciute, Vilma, Fürnrohr, Barbara G., Meister, Silke, Munoz, Luis, Heyder, Petra, De Marchis, Francesco, Bianchi, Marco E., Kirschning, Carsten, Wagner, Hermann, Manfredi, Angelo A., Kalden, Joachim R., Schett, Georg, Rovere-Querini, Patrizia, Herrmann, Martin, Voll, Reinhard E.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2605236/
https://www.ncbi.nlm.nih.gov/pubmed/19064698
http://dx.doi.org/10.1084/jem.20081165