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Induction of inflammatory and immune responses by HMGB1–nucleosome complexes: implications for the pathogenesis of SLE
Autoantibodies against double-stranded DNA (dsDNA) and nucleosomes represent a hallmark of systemic lupus erythematosus (SLE). However, the mechanisms involved in breaking the immunological tolerance against these poorly immunogenic nuclear components are not fully understood. Impaired phagocytosis...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2605236/ https://www.ncbi.nlm.nih.gov/pubmed/19064698 http://dx.doi.org/10.1084/jem.20081165 |