Opposing Effects of Sirtuins on Neuronal Survival: SIRT1-Mediated Neuroprotection Is Independent of Its Deacetylase Activity

BACKGROUND: Growing evidence suggests that sirtuins, a family of seven distinct NAD-dependent enzymes, are involved in the regulation of neuronal survival. Indeed, SIRT1 has been reported to protect against neuronal death, while SIRT2 promotes neurodegeneration. The effect of SIRTs 3–7 on the regula...

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Detalles Bibliográficos
Autores principales: Pfister, Jason A., Ma, Chi, Morrison, Brad E., D'Mello, Santosh R.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2605257/
https://www.ncbi.nlm.nih.gov/pubmed/19116652
http://dx.doi.org/10.1371/journal.pone.0004090

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2605257/
https://www.ncbi.nlm.nih.gov/pubmed/19116652
http://dx.doi.org/10.1371/journal.pone.0004090

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