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Synthesis of imidazol-1-yl-acetic acid hydrochloride: A key intermediate for zoledronic acid
A convenient and practical synthesis of imidazol-1-yl-acetic acid hydrochloride was achieved via N-alkylation of imidazole using tert-butyl chloroacetate followed by a non-aqueous ester cleavage of the resulting imidazol-1-yl-acetic acid tert-butyl ester in the presence of titanium tetrachloride. Th...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Beilstein-Institut
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2605618/ https://www.ncbi.nlm.nih.gov/pubmed/19104672 http://dx.doi.org/10.3762/bjoc.4.42 |