Slc11a1 Enhances the Autoimmune Diabetogenic T-Cell Response by Altering Processing and Presentation of Pancreatic Islet Antigens

OBJECTIVE—Efforts to map non–major histocompatibility complex (MHC) genes causing type 1 diabetes in NOD mice identified Slc11a1, formerly Nramp1, as the leading candidate gene in the Idd5.2 region. Slc11a1 is a membrane transporter of bivalent cations that is expressed in late endosomes and lysosom...

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Detalles Bibliográficos
Autores principales: Dai, Yang D., Marrero, Idania G., Gros, Philippe, Zaghouani, Habib, Wicker, Linda S., Sercarz, Eli E.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2009
Materias:
Immunology and Transplantation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2606865/
https://www.ncbi.nlm.nih.gov/pubmed/18984740
http://dx.doi.org/10.2337/db07-1608

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2606865/
https://www.ncbi.nlm.nih.gov/pubmed/18984740
http://dx.doi.org/10.2337/db07-1608

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