Methyltransferase Set7/9 Maintains Transcription and Euchromatin Structure at Islet-Enriched Genes

OBJECTIVE—The activation of β-cell genes, particularly of those encoding preproinsulin, requires an appropriate euchromatin (or “open”) DNA template characterized by hypermethylation of Lys4 of histone H3. We hypothesized that this modification is maintained in islet β-cells by the action of the his...

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Detalles Bibliográficos
Autores principales: Deering, Tye G., Ogihara, Takeshi, Trace, Anthony P., Maier, Bernhard, Mirmira, Raghavendra G.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2009
Materias:
Islet Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2606870/
https://www.ncbi.nlm.nih.gov/pubmed/18984737
http://dx.doi.org/10.2337/db08-1150

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2606870/
https://www.ncbi.nlm.nih.gov/pubmed/18984737
http://dx.doi.org/10.2337/db08-1150

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