Restoration of Hepatic Glucokinase Expression Corrects Hepatic Glucose Flux and Normalizes Plasma Glucose in Zucker Diabetic Fatty Rats

OBJECTIVE—We examined in 20-week-old Zucker diabetic fatty (ZDF) rats whether restoration of hepatic glucokinase (GK) expression would alter hepatic glucose flux and improve hyperglycemia. RESEARCH DESIGN AND METHODS—ZDF rats were treated at various doses with an adenovirus that directs the expressi...

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Detalles Bibliográficos
Autores principales: Torres, Tracy P., Catlin, ReEtta L., Chan, Robert, Fujimoto, Yuka, Sasaki, Noriyasu, Printz, Richard L., Newgard, Christopher B., Shiota, Masakazu
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2009
Materias:
Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2606896/
https://www.ncbi.nlm.nih.gov/pubmed/18952838
http://dx.doi.org/10.2337/db08-1119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2606896/
https://www.ncbi.nlm.nih.gov/pubmed/18952838
http://dx.doi.org/10.2337/db08-1119

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