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Mutations at the Signature Sequence of CFTR Create a Cd(2+)-gated Chloride Channel
The canonical sequence LSGGQ, also known as the signature sequence, defines the adenosine triphosphate (ATP)-binding cassette transporter superfamily. Crystallographic studies reveal that the signature sequence, together with the Walker A and Walker B motifs, forms the ATP-binding pocket upon dimeri...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2606936/ https://www.ncbi.nlm.nih.gov/pubmed/19114635 http://dx.doi.org/10.1085/jgp.200810049 |