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Amphiphilic Blockers Punch through a Mutant CLC-0 Pore
Intracellularly applied amphiphilic molecules, such as p-chlorophenoxy acetate (CPA) and octanoate, block various pore-open mutants of CLC-0. The voltage-dependent block of a particular pore-open mutant, E166G, was found to be multiphasic. In symmetrical 140 mM Cl(−), the apparent affinity of the bl...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2606939/ https://www.ncbi.nlm.nih.gov/pubmed/19088382 http://dx.doi.org/10.1085/jgp.200810005 |