Blocking Pore-open Mutants of CLC-0 by Amphiphilic Blockers

The blockade of CLC-0 chloride channels by p-chlorophenoxy acetate (CPA) has been thought to be state dependent; the conformational change of the channel pore during the “fast gating” alters the CPA binding affinity. Here, we examine the mechanism of CPA blocking in pore-open mutants of CLC-0 in whi...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Xiao-Dong, Tseng, Pang-Yen, Yu, Wei-Ping, Chen, Tsung-Yu
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2606940/
https://www.ncbi.nlm.nih.gov/pubmed/19088381
http://dx.doi.org/10.1085/jgp.200810004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2606940/
https://www.ncbi.nlm.nih.gov/pubmed/19088381
http://dx.doi.org/10.1085/jgp.200810004

Ejemplares similares