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Blocking Pore-open Mutants of CLC-0 by Amphiphilic Blockers

The blockade of CLC-0 chloride channels by p-chlorophenoxy acetate (CPA) has been thought to be state dependent; the conformational change of the channel pore during the “fast gating” alters the CPA binding affinity. Here, we examine the mechanism of CPA blocking in pore-open mutants of CLC-0 in whi...

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Detalles Bibliográficos
Autores principales:	Zhang, Xiao-Dong, Tseng, Pang-Yen, Yu, Wei-Ping, Chen, Tsung-Yu
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2009
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2606940/ https://www.ncbi.nlm.nih.gov/pubmed/19088381 http://dx.doi.org/10.1085/jgp.200810004

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