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Local Anesthetics Disrupt Energetic Coupling between the Voltage-sensing Segments of a Sodium Channel

Local anesthetics block sodium channels in a state-dependent fashion, binding with higher affinity to open and/or inactivated states. Gating current measurements show that local anesthetics immobilize a fraction of the gating charge, suggesting that the movement of voltage sensors is modified when a...

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Detalles Bibliográficos
Autores principales: Muroi, Yukiko, Chanda, Baron
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2606943/
https://www.ncbi.nlm.nih.gov/pubmed/19088384
http://dx.doi.org/10.1085/jgp.200810103