The sympathetic tone mediates leptin's inhibition of insulin secretion by modulating osteocalcin bioactivity

The osteoblast-secreted molecule osteocalcin favors insulin secretion, but how this function is regulated in vivo by extracellular signals is for now unknown. In this study, we show that leptin, which instead inhibits insulin secretion, partly uses the sympathetic nervous system to fulfill this func...

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Detalles Bibliográficos
Autores principales: Hinoi, Eiichi, Gao, Nan, Jung, Dae Young, Yadav, Vijay, Yoshizawa, Tatsuya, Myers, Martin G., Chua, Streamson C., Kim, Jason K., Kaestner, Klaus H., Karsenty, Gerard
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2606962/
https://www.ncbi.nlm.nih.gov/pubmed/19103808
http://dx.doi.org/10.1083/jcb.200809113

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2606962/
https://www.ncbi.nlm.nih.gov/pubmed/19103808
http://dx.doi.org/10.1083/jcb.200809113

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