Proteolytic fragments of laminin promote excitotoxic neurodegeneration by up-regulation of the KA1 subunit of the kainate receptor

Degradation of the extracellular matrix (ECM) protein laminin contributes to excitotoxic cell death in the hippocampus, but the mechanism of this effect is unknown. To study this process, we disrupted laminin γ1 (lamγ1) expression in the hippocampus. Lamγ1 knockout (KO) and control mice had similar...

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Detalles Bibliográficos
Autores principales: Chen, Zu-Lin, Yu, Huaxu, Yu, Wei-Ming, Pawlak, Robert, Strickland, Sidney
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2606967/
https://www.ncbi.nlm.nih.gov/pubmed/19114596
http://dx.doi.org/10.1083/jcb.200803107

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2606967/
https://www.ncbi.nlm.nih.gov/pubmed/19114596
http://dx.doi.org/10.1083/jcb.200803107

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