Gain of Function Mutations in CgPDR1 of Candida glabrata Not Only Mediate Antifungal Resistance but Also Enhance Virulence

CgPdr1p is a Candida glabrata Zn(2)-Cys(6) transcription factor involved in the regulation of the ABC-transporter genes CgCDR1, CgCDR2, and CgSNQ2, which are mediators of azole resistance. Single-point mutations in CgPDR1 are known to increase the expression of at least CgCDR1 and CgCDR2 and thus to...

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Detalles Bibliográficos
Autores principales: Ferrari, Sélène, Ischer, Françoise, Calabrese, David, Posteraro, Brunella, Sanguinetti, Maurizio, Fadda, Giovanni, Rohde, Bettina, Bauser, Christopher, Bader, Oliver, Sanglard, Dominique
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2607542/
https://www.ncbi.nlm.nih.gov/pubmed/19148266
http://dx.doi.org/10.1371/journal.ppat.1000268

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2607542/
https://www.ncbi.nlm.nih.gov/pubmed/19148266
http://dx.doi.org/10.1371/journal.ppat.1000268

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