P38 MAP kinase inhibitors as potential therapeutics for the treatment of joint degeneration and pain associated with osteoarthritis

BACKGROUND: Evaluate the potential role of p38 inhibitors for the treatment of osteoarthritis using an animal model of joint degeneration (iodoacetate-induced arthritis) and a pain model (Hargraeves assay). METHODS: P38 kinase activity was evaluated in a kinase assay by measuring the amount of phosp...

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Detalles Bibliográficos
Autores principales: Brown, Kimberly K, Heitmeyer, Sandra A, Hookfin, Erin B, Hsieh, Lily, Buchalova, Maria, Taiwo, Yetunde O, Janusz, Michael J
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2612656/
https://www.ncbi.nlm.nih.gov/pubmed/19055838
http://dx.doi.org/10.1186/1476-9255-5-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2612656/
https://www.ncbi.nlm.nih.gov/pubmed/19055838
http://dx.doi.org/10.1186/1476-9255-5-22

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