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Lack of anabolic response to skeletal loading in mice with targeted disruption of the pleiotrophin gene
BACKGROUND: In a previous study we showed, using the whole genome microarray approach, that pleiotrophin (PTN) expression was increased by 4-fold in response to mechanical loading (ML) in a good responder C57BL/6J (B6) mice. To address PTN role in mediating ML effects on bone formation, we first eva...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2612677/ https://www.ncbi.nlm.nih.gov/pubmed/19046452 http://dx.doi.org/10.1186/1756-0500-1-124 |