Discovery of a Non-Peptidic Inhibitor of West Nile Virus NS3 Protease by High-Throughput Docking

BACKGROUND: The non-structural 3 protease (NS3pro) is an essential flaviviral enzyme and therefore one of the most promising targets for drug development against West Nile virus (WNV) and dengue infections. METHODOLOGY: In this work, a small-molecule inhibitor of the WNV NS3pro has been identified b...

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Detalles Bibliográficos
Autores principales: Ekonomiuk, Dariusz, Su, Xun-Cheng, Ozawa, Kiyoshi, Bodenreider, Christophe, Lim, Siew Pheng, Yin, Zheng, Keller, Thomas H., Beer, David, Patel, Viral, Otting, Gottfried, Caflisch, Amedeo, Huang, Danzhi
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613028/
https://www.ncbi.nlm.nih.gov/pubmed/19159012
http://dx.doi.org/10.1371/journal.pntd.0000356

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613028/
https://www.ncbi.nlm.nih.gov/pubmed/19159012
http://dx.doi.org/10.1371/journal.pntd.0000356

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