Sensitive, specific polymorphism discovery in bacteria using massively parallel sequencing

Our variant ascertainment algorithm VAAL uses massively parallel DNA sequence data to identify differences between bacterial genomes at high sensitivity and specificity. VAAL found ~98% of differences (including large indels) between pairs of strains from three species while calling no false positiv...

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Detalles Bibliográficos
Autores principales: Nusbaum, Chad, Ohsumi, Toshiro K., Gomez, James, Aquadro, John, Victor, Thomas C., Warren, Robert M., Hung, Deborah T., Birren, Bruce W., Lander, Eric S., Jaffe, David B.
Formato: Texto
Lenguaje:English
Publicado: 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613166/
https://www.ncbi.nlm.nih.gov/pubmed/19079253
http://dx.doi.org/10.1038/nmeth.1286

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613166/
https://www.ncbi.nlm.nih.gov/pubmed/19079253
http://dx.doi.org/10.1038/nmeth.1286

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