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Synergistic Apoptosis Induction in Leukemic Cells by the Phosphatase Inhibitor Salubrinal and Proteasome Inhibitors

BACKGROUND: Cells adapt to endoplasmic reticulum (ER)-stress by arresting global protein synthesis while simultaneously activating specific transcription factors and their downstream targets. These processes are mediated in part by the phosphorylation-dependent inactivation of the translation initia...

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Detalles Bibliográficos
Autor principal: Drexler, Hannes C. A.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613525/
https://www.ncbi.nlm.nih.gov/pubmed/19129918
http://dx.doi.org/10.1371/journal.pone.0004161