Smad gene expression in pulmonary fibroblasts: indications for defective ECM repair in COPD

BACKGROUND: Chronic Obstructive Pulmonary Disease (COPD) is characterized by defective extracellular matrix (ECM) turnover as a result of prolonged cigarette smoking. Fibroblasts have a central role in ECM turnover. The TGFβ induced Smad pathway provides intracellular signals to regulate ECM product...

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Detalles Bibliográficos
Autores principales: Zandvoort, Andre, Postma, Dirkje S, Jonker, Marnix R, Noordhoek, Jacobien A, Vos, Johannes TWM, Timens, Wim
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613883/
https://www.ncbi.nlm.nih.gov/pubmed/19087346
http://dx.doi.org/10.1186/1465-9921-9-83

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613883/
https://www.ncbi.nlm.nih.gov/pubmed/19087346
http://dx.doi.org/10.1186/1465-9921-9-83

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