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Smad gene expression in pulmonary fibroblasts: indications for defective ECM repair in COPD

BACKGROUND: Chronic Obstructive Pulmonary Disease (COPD) is characterized by defective extracellular matrix (ECM) turnover as a result of prolonged cigarette smoking. Fibroblasts have a central role in ECM turnover. The TGFβ induced Smad pathway provides intracellular signals to regulate ECM product...

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Detalles Bibliográficos
Autores principales:	Zandvoort, Andre, Postma, Dirkje S, Jonker, Marnix R, Noordhoek, Jacobien A, Vos, Johannes TWM, Timens, Wim
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2008
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613883/ https://www.ncbi.nlm.nih.gov/pubmed/19087346 http://dx.doi.org/10.1186/1465-9921-9-83

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