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A Simple Derivation of the Distribution of Pairwise Local Protein Sequence Alignment Scores
Confidence in pairwise alignments of biological sequences, obtained by various methods such as Blast or Smith-Waterman, is critical for automatic analyses of genomic data. In the asymptotic limit of long sequences, the Karlin-Altschul model computes a P-value assuming that the number of high scoring...
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| Formato: | Texto |
| Lenguaje: | English |
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Libertas Academica
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2614193/ https://www.ncbi.nlm.nih.gov/pubmed/19204806 |