The exosome contains domains with specific endoribonuclease, exoribonuclease and cytoplasmic mRNA decay activities

The eukaryotic exosome is a ten subunit 3′ exoribonuclease complex responsible for many RNA processing and degradation reactions. How the exosome accomplishes this is unknown. We show that the PIN domain of Rrp44 is an endoribonuclease. The activity of the PIN domain prefers RNA with a 5′ phosphate,...

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Detalles Bibliográficos
Autores principales: Schaeffer, Daneen, Tsanova, Borislava, Barbas, Ana, Reis, Filipa Pereira, Dastidar, Eeshita Ghosh, Sanchez-Rotunno, Maya, Arraiano, Cecilia Maria, van Hoof, Ambro
Formato: Texto
Lenguaje:English
Publicado: 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2615074/
https://www.ncbi.nlm.nih.gov/pubmed/19060898
http://dx.doi.org/10.1038/nsmb.1528

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2615074/
https://www.ncbi.nlm.nih.gov/pubmed/19060898
http://dx.doi.org/10.1038/nsmb.1528

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