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The exosome contains domains with specific endoribonuclease, exoribonuclease and cytoplasmic mRNA decay activities
The eukaryotic exosome is a ten subunit 3′ exoribonuclease complex responsible for many RNA processing and degradation reactions. How the exosome accomplishes this is unknown. We show that the PIN domain of Rrp44 is an endoribonuclease. The activity of the PIN domain prefers RNA with a 5′ phosphate,...
| Autores principales: | , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2615074/ https://www.ncbi.nlm.nih.gov/pubmed/19060898 http://dx.doi.org/10.1038/nsmb.1528 |