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Misfolding of Proteins with a Polyglutamine Expansion Is Facilitated by Proteasomal Chaperones
Deposition of misfolded proteins with a polyglutamine expansion is a hallmark of Huntington disease and other neurodegenerative disorders. Impairment of the proteolytic function of the proteasome has been reported to be both a cause and a consequence of polyglutamine accumulation. Here we found that...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2615503/ https://www.ncbi.nlm.nih.gov/pubmed/18986984 http://dx.doi.org/10.1074/jbc.M806256200 |