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Misfolding of Proteins with a Polyglutamine Expansion Is Facilitated by Proteasomal Chaperones

Deposition of misfolded proteins with a polyglutamine expansion is a hallmark of Huntington disease and other neurodegenerative disorders. Impairment of the proteolytic function of the proteasome has been reported to be both a cause and a consequence of polyglutamine accumulation. Here we found that...

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Detalles Bibliográficos
Autores principales:	Rousseau, Erwann, Kojima, Rieko, Hoffner, Guylaine, Djian, Philippe, Bertolotti, Anne
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2009
Materias:	Protein Structure and Folding
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2615503/ https://www.ncbi.nlm.nih.gov/pubmed/18986984 http://dx.doi.org/10.1074/jbc.M806256200

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