Array-based evolution of DNA aptamers allows modelling of an explicit sequence-fitness landscape

Mapping the landscape of possible macromolecular polymer sequences to their fitness in performing biological functions is a challenge across the biosciences. A paradigm is the case of aptamers, nucleic acids that can be selected to bind particular target molecules. We have characterized the sequence...

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Detalles Bibliográficos
Autores principales: Knight, Christopher G., Platt, Mark, Rowe, William, Wedge, David C., Khan, Farid, Day, Philip J. R., McShea, Andy, Knowles, Joshua, Kell, Douglas B.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2615635/
https://www.ncbi.nlm.nih.gov/pubmed/19029139
http://dx.doi.org/10.1093/nar/gkn899

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2615635/
https://www.ncbi.nlm.nih.gov/pubmed/19029139
http://dx.doi.org/10.1093/nar/gkn899

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