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Array-based evolution of DNA aptamers allows modelling of an explicit sequence-fitness landscape
Mapping the landscape of possible macromolecular polymer sequences to their fitness in performing biological functions is a challenge across the biosciences. A paradigm is the case of aptamers, nucleic acids that can be selected to bind particular target molecules. We have characterized the sequence...
| Autores principales: | , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2615635/ https://www.ncbi.nlm.nih.gov/pubmed/19029139 http://dx.doi.org/10.1093/nar/gkn899 |